Science (New York, N.Y.) · 2022
Microglia-mediated degradation of perineuronal nets promotes pain.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Tansley Shannon, Gu Ning, Guzmán Alba Ureña, Cai Weihua, Wong Calvin, Lister Kevin C, Muñoz-Pino Einer, Yousefpour Noosha, Roome R Brian, Heal Jordyn, Wu Neil, Castonguay Annie, Lean Graham, Muir Elizabeth M, Kania Artur, Prager-Khoutorsky Masha, Zhang Ji, Gkogkas Christos G, Fawcett James W, Diatchenko Luda, Ribeiro-da-Silva Alfredo, De Koninck Yves, Mogil Jeffrey S, Khoutorsky Arkady
Аннотация
Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets (PNNs), in lamina I of the spinal cord dorsal horn. Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury-induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity.