International journal of clinical and experimental medicine · 2015
Clinical significance of C-reactive protein levels in the determination of pathological type of acute appendicitis.
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Qi Feng-Qin, Zhang Bo
Аннотация
OBJECTIVE: To investigate the significance of C-reactive protein (CRP) in the discrimination of acute appendicitis pathology and its guiding role in the timing of surgery.
METHODS: 307 patients in our hospital from July 2012 to December 2013 were selected, who received appendectomy and simultaneous detections of WBC, neutrophil percentage and CRP; and Logistic regression analysis and Roc analysis of these indicators were conducted; Roc curve was drawn.
RESULTS: Logistic regression analysis showed that the proportion of neutrophils and CRP were the risk factors to determine gangrenous appendicitis, but the box chart and Roc curves showed that C-reactive protein was superior to neutrophil classification in determining gangrenous appendicitis (areas under the curve were 0.882 and 0.667 respectively), and the best diagnostic cutoff value was 44.42 mg/L (sensitivity 73.1%, specificity 89.5%).
CONCLUSION: C-reactive protein levels can help distinguish pathological types of acute appendicitis, which can be used as a reference index for surgery determination.
METHODS: 307 patients in our hospital from July 2012 to December 2013 were selected, who received appendectomy and simultaneous detections of WBC, neutrophil percentage and CRP; and Logistic regression analysis and Roc analysis of these indicators were conducted; Roc curve was drawn.
RESULTS: Logistic regression analysis showed that the proportion of neutrophils and CRP were the risk factors to determine gangrenous appendicitis, but the box chart and Roc curves showed that C-reactive protein was superior to neutrophil classification in determining gangrenous appendicitis (areas under the curve were 0.882 and 0.667 respectively), and the best diagnostic cutoff value was 44.42 mg/L (sensitivity 73.1%, specificity 89.5%).
CONCLUSION: C-reactive protein levels can help distinguish pathological types of acute appendicitis, which can be used as a reference index for surgery determination.