Clinical Manifestations and Associated Disease States with Mycoplasma genitalium Infection: Narrative Review and State of the Literature, 2015-2025.

Mycoplasma genitalium (MG) can be asymptomatic or cause a symptomatic infection. Prevalence is associated with demographic factors as well as risk factors for other sexually transmitted infections, such as increasing number of sex partners. MG is common at genitourinary and rectal sites, and unusual in the pharynx. Coinfections are common. Cervicitis, urethritis, and pelvic inflammatory disease are the most common associated disease states, though many other less common clinical manifestations have been described in individuals with MG infection. Here we review the extensive literature from 2015 through 2025 on these topics and provide an overview for interested clinicians and researchers.