Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
Association between interleukin-10 gene polymorphisms and multiple sclerosis susceptibility: evidence from a meta-analysis.
СтатьяМетаанализНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Xu Yue-Long, Niu Yu-Ming
Аннотация
OBJECTIVE: Epidemiological studies have suggested that single nucleotide polymorphisms (SNPs) in the interleukin-10 (IL-10) gene may contribute to the etiology of multiple sclerosis (MS). However, the results to date have been inconsistent, even contradictory.
METHODS: A meta-analysis was conducted to investigate the potential association between IL-10 SNPs and MS susceptibility. Five English-language databases (PubMed, Embase, Web of Science, CNKI, and Wanfang) were searched for relevant studies. Crude odds ratios (OR) and 95% confidence intervals (CI) were calculated to assess the relationship between IL-10-1082 A > G (rs1800896), -819T > C (rs1800871), -592 A > C (rs1800872) polymorphisms, their haplotypes, and MS susceptibility. Publication bias, sensitivity analyses, and cumulative analyses were performed to evaluate the robustness and reliability of the findings.
RESULTS: Fourteen articles (30 independent case-control studies) were included, revealing significant associations between the - 1082 A > G polymorphism and MS susceptibility in the general population (G vs. A: OR = 1.14, 95%CI = 1.05-1.24, P = 0.002, I2 = 18.6%; AG vs. AA: OR = 1.32, 95%CI = 1.15-1.52, P < 0.001, I2 = 36.1%; GG vs. AA: OR = 1.30, 95%CI = 1.10-1.55, P = 0.003, I2 = 25.0%; AG + GG vs. AA: OR = 1.31, 95%CI = 1.15-1.49, P < 0.001, I2 = 35.8%) and several subgroup models. Furthermore, the mutant GCC haplotype also exhibited a significant risk on MS susceptibility.
CONCLUSION: In summary, this current meta-analysis suggested that the IL-10 gene polymorphisms may be the substantial factors for the development of MS.
METHODS: A meta-analysis was conducted to investigate the potential association between IL-10 SNPs and MS susceptibility. Five English-language databases (PubMed, Embase, Web of Science, CNKI, and Wanfang) were searched for relevant studies. Crude odds ratios (OR) and 95% confidence intervals (CI) were calculated to assess the relationship between IL-10-1082 A > G (rs1800896), -819T > C (rs1800871), -592 A > C (rs1800872) polymorphisms, their haplotypes, and MS susceptibility. Publication bias, sensitivity analyses, and cumulative analyses were performed to evaluate the robustness and reliability of the findings.
RESULTS: Fourteen articles (30 independent case-control studies) were included, revealing significant associations between the - 1082 A > G polymorphism and MS susceptibility in the general population (G vs. A: OR = 1.14, 95%CI = 1.05-1.24, P = 0.002, I2 = 18.6%; AG vs. AA: OR = 1.32, 95%CI = 1.15-1.52, P < 0.001, I2 = 36.1%; GG vs. AA: OR = 1.30, 95%CI = 1.10-1.55, P = 0.003, I2 = 25.0%; AG + GG vs. AA: OR = 1.31, 95%CI = 1.15-1.49, P < 0.001, I2 = 35.8%) and several subgroup models. Furthermore, the mutant GCC haplotype also exhibited a significant risk on MS susceptibility.
CONCLUSION: In summary, this current meta-analysis suggested that the IL-10 gene polymorphisms may be the substantial factors for the development of MS.