Head & neck · 2026
Biomarkers Associated With Extranodal Extension (ENE) in Oropharyngeal Squamous Cell Carcinoma (OPSCC): A Systematic Review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Williams Lauren C, Lorenzo Naishaliz, Ladenheim Alexander, Mehra Saral, Judson Benjamin L, Pai Sara I, Verma Avanti, Sayed Zafar, Clohessy James, Roche Ansley M
Аннотация
BACKGROUND: Detection of extranodal extension (ENE) can guide treatment planning for patients with oropharyngeal squamous cell carcinoma (OPSCC). This systematic review identifies molecular biomarkers predictive of ENE in both Human Papillomavirus (HPV)-positive and HPV-negative OPSCC.
METHODS: A systematic review was conducted for relevant articles published between 1996 and July 2025. Studies were included if they included exclusively patients with OPSCC and evaluated the presence of ENE based on molecular biomarkers.
RESULTS: Ten studies met inclusion criteria. Tumor tissue modified viral (TTMV)-HPV DNA was not associated with ENE. Biomarkers associated with ENE included NOTCH-1 and WNT mutations and expression of podoplanin, Her3, and myoferlin. These biomarkers have also been linked with epithelial-mesenchymal transition (EMT) in cancer cells.
CONCLUSIONS: Multiple genomic and molecular biomarkers have been identified in association with ENE in OPSCC, suggesting that ENE is characterized by an EMT phenotype.
METHODS: A systematic review was conducted for relevant articles published between 1996 and July 2025. Studies were included if they included exclusively patients with OPSCC and evaluated the presence of ENE based on molecular biomarkers.
RESULTS: Ten studies met inclusion criteria. Tumor tissue modified viral (TTMV)-HPV DNA was not associated with ENE. Biomarkers associated with ENE included NOTCH-1 and WNT mutations and expression of podoplanin, Her3, and myoferlin. These biomarkers have also been linked with epithelial-mesenchymal transition (EMT) in cancer cells.
CONCLUSIONS: Multiple genomic and molecular biomarkers have been identified in association with ENE in OPSCC, suggesting that ENE is characterized by an EMT phenotype.