Pharmaceutics · 2024
L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity.
СтатьяНазвание и аннотация: Перевод в очереди
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Ramírez-Contreras Diego, Vázquez-Rodríguez Sergio, García-García Amalia, Noriega Lisset, Mendoza Angel, Sánchez-Gaytán Brenda L, Meléndez Francisco J, Castro María Eugenia, Cárdenas-García Maura, González-Vergara Enrique
Аннотация
Citrulline (C6H13N3O3) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal ureido group on its aliphatic chain, which also appears to coordinate. Here, two new mixed complexes of citrulline were made with 1,10-phenanthroline and 2,2'-bipyridine. These compounds, once dissolved in water, gave aquo-complexes that were subject to DFT studies and in vitro toxicity studies on cancer cell lines (HeLa, MDA-MB-231, HCT 15, and MCF7) showed promising results. Docking studies with DNA were also conducted, indicating potential anticancer properties.