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DOI 10.1093/infdis/jiag154

Медицинская библиотека · The Journal of infectious diseases · 2026

Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients With HIV.

Sulaiman Andrew, Tamil Selvan Miruthula, Yang Ping, Zhu Xianming, Eby Yolanda, Benner Sarah E, Fernandez Reinaldo E, Hussain Sarah, Brown Diane, Desai Niraj, Florman Sander, Rana Meenakshi M, Friedman-Moraco Rachel, Pereira Marcus R, Mehta Shikha, Stock Peter, Gilbert Alexander, Morris Michele I, Stosor Valentina, Mehta Sapna A, Small Catherine B, Ranganna Karthik, Santos Carlos A Q, Aslam Saima, Malinis Maricar, Elias Nahel, Blumberg Emily A, Massie Allan, Smith Melissa L, Morsheimer Megan, Laird Gregory M, Siliciano Robert, Segev Dorry L, Durand Christine M, Redd Andrew D, Tobian Aaron A R

Клиническое исследованиеСтатьяМногоцентровое исследованиеПеревод в очереди

Аннотация

People with HIV-1 have higher risk for rejection after kidney transplantation but the mechanism is poorly understood. As HIV latency promotes immune dysregulation and chronic inflammation, we evaluated whether the size of the HIV latent viral reservoir (LVR) at baseline and through 52-weeks is associated with rejection in kidney transplant recipients with HIV from donors with and without HIV. Using the intact proviral DNA assay, we found no differences in the LVR between those who experienced rejection (n = 14) versus those who did not (N = 55) regardless of donor HIV status. These data support the feasibility of HIV+ to HIV+ organ transplantation. Clinical Trials Registration. NCT03500315.

Для цитирования: Sulaiman Andrew, Tamil Selvan Miruthula, Yang Ping, Zhu Xianming, Eby Yolanda, Benner Sarah E, Fernandez Reinaldo E, Hussain Sarah, Brown Diane, Desai Niraj, Florman Sander, Rana Meenakshi M, Friedman-Moraco Rachel, Pereira Marcus R, Mehta Shikha, Stock Peter, Gilbert Alexander, Morris Michele I, Stosor Valentina, Mehta Sapna A, Small Catherine B, Ranganna Karthik, Santos Carlos A Q, Aslam Saima, Malinis Maricar, Elias Nahel, Blumberg Emily A, Massie Allan, Smith Melissa L, Morsheimer Megan, Laird Gregory M, Siliciano Robert, Segev Dorry L, Durand Christine M, Redd Andrew D, Tobian Aaron A R. Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients With HIV.. The Journal of infectious diseases. 2026. DOI: 10.1093/infdis/jiag154.

Предметные рубрики MeSH

AdultFemaleHumansMaleMiddle AgedDNA, ViralGraft RejectionHIV InfectionsHIV-1Kidney TransplantationTransplant RecipientsViral LoadVirus Latency
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