Archives of ophthalmology (Chicago, Ill. : 1960) · 2002
Docetaxel secretion in tears: association with lacrimal drainage obstruction.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Esmaeli Bita, Ahmadi M Amir, Rivera Edgardo, Valero Vicente, Hutto Toni, Jackson Denise M, Newman Robert A
Аннотация
OBJECTIVE: To test the hypothesis that docetaxel may be secreted in tears after intravenous infusion.
DESIGN: Prospective pilot trial.
PATIENTS AND METHODS: Tear fluid was collected from 4 patients receiving docetaxel weekly and 2 patients receiving docetaxel every 3 weeks as a single agent for the treatment of metastatic breast cancer. Tear samples were collected once prior to and again within 30 minutes following the end of the 1-hour docetaxel infusion. A blood sample was also obtained after infusion. The tear and plasma samples were analyzed for drug content using high-performance liquid chromatography and tandem mass spectrometry.
RESULTS: Docetaxel was found in the tear samples collected from all 6 patients.
CONCLUSION: The secretion of docetaxel in tears may be a mechanism for canalicular inflammation and tear drainage obstruction, which are known to occur as an adverse effect of the drug.
DESIGN: Prospective pilot trial.
PATIENTS AND METHODS: Tear fluid was collected from 4 patients receiving docetaxel weekly and 2 patients receiving docetaxel every 3 weeks as a single agent for the treatment of metastatic breast cancer. Tear samples were collected once prior to and again within 30 minutes following the end of the 1-hour docetaxel infusion. A blood sample was also obtained after infusion. The tear and plasma samples were analyzed for drug content using high-performance liquid chromatography and tandem mass spectrometry.
RESULTS: Docetaxel was found in the tear samples collected from all 6 patients.
CONCLUSION: The secretion of docetaxel in tears may be a mechanism for canalicular inflammation and tear drainage obstruction, which are known to occur as an adverse effect of the drug.