The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.

OBJECTIVE

This study aimed to examine the association of rs7041 polymorphism with PCOS, as well as infertility and recurrent pregnancy loss (RPL) in PCOS patients.

RESULTS

Genotype analysis showed that the GT genotype and the T allele of the rs7041 polymorphism were associated with increased odds of PCOS. (OR: 2.8 95% CI [1.48-5.33], p = 0.002, and OR: 2.27 95% CI [1.2-4.28], p = 0.01, respectively). Furthermore, the GT genotype and T allele of the rs7041 polymorphism were associated with increased odds of infertility in women with PCOS. (OR: 40.55 95% CI [5.34-307.7], p < 0.0001, and OR: 30.667 95% CI [4.05-232.19], p = 0.001, respectively). Conversely, no significant association was observed between genotypes and RPL in women with PCOS. Luteinizing hormone (LH) levels were significantly higher in individuals with the T allele compared to those with the G allele.