Медицинская библиотека · Molecular psychiatry · 2020
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
de las Fuentes Lisa, Sung Yun Ju, Noordam Raymond, Winkler Thomas, Feitosa Mary F, Schwander Karen, Bentley Amy R, Brown Michael R, Guo Xiuqing, Manning Alisa, Chasman Daniel I, Aschard Hugues, Bartz Traci M, Bielak Lawrence F, Campbell Archie, Cheng Ching-Yu, Dorajoo Rajkumar, Hartwig Fernando P, Horimoto A R V R, Li Changwei, Li-Gao Ruifang, Liu Yongmei, Marten Jonathan, Musani Solomon K, Ntalla Ioanna, Rankinen Tuomo, Richard Melissa, Sim Xueling, Smith Albert V, Tajuddin Salman M, Tayo Bamidele O, Vojinovic Dina, Warren Helen R, Xuan Deng, Alver Maris, Boissel Mathilde, Chai Jin-Fang, Chen Xu, Christensen Kaare, Divers Jasmin, Evangelou Evangelos, Gao Chuan, Girotto Giorgia, Harris Sarah E, He Meian, Hsu Fang-Chi, Kühnel Brigitte, Laguzzi Federica, Li Xiaoyin, Lyytikäinen Leo-Pekka, Nolte Ilja M, Poveda Alaitz, Rauramaa Rainer, Riaz Muhammad, Rueedi Rico, Shu Xiao-Ou, Snieder Harold, Sofer Tamar, Takeuchi Fumihiko, Verweij Niek, Ware Erin B, Weiss Stefan, Yanek Lisa R, Amin Najaf, Arking Dan E, Arnett Donna K, Bergmann Sven, Boerwinkle Eric, Brody Jennifer A, Broeckel Ulrich, Brumat Marco, Burke Gregory, Cabrera Claudia P, Canouil Mickaël, Chee Miao Li, Chen Yii-Der Ida, Cocca Massimiliano, Connell John, de Silva H Janaka, de Vries Paul S, Eiriksdottir Gudny, Faul Jessica D, Fisher Virginia, Forrester Terrence, Fox Ervin F, Friedlander Yechiel, Gao He, Gigante Bruna, Giulianini Franco, Gu Chi Charles, Gu Dongfeng, Harris Tamara B, He Jiang, Heikkinen Sami, Heng Chew-Kiat, Hunt Steven, Ikram M Arfan, Irvin Marguerite R, Kähönen Mika, Kavousi Maryam, Khor Chiea Chuen, Kilpeläinen Tuomas O, Koh Woon-Puay, Komulainen Pirjo, Kraja Aldi T, Krieger J E, Langefeld Carl D, Li Yize, Liang Jingjing, Liewald David C M, Liu Ching-Ti, Liu Jianjun, Lohman Kurt K, Mägi Reedik, McKenzie Colin A, Meitinger Thomas, Metspalu Andres, Milaneschi Yuri, Milani Lili, Mook-Kanamori Dennis O, Nalls Mike A, Nelson Christopher P, Norris Jill M, O'Connell Jeff, Ogunniyi Adesola, Padmanabhan Sandosh, Palmer Nicholette D, Pedersen Nancy L, Perls Thomas, Peters Annette, Petersmann Astrid, Peyser Patricia A, Polasek Ozren, Porteous David J, Raffel Leslie J, Rice Treva K, Rotter Jerome I, Rudan Igor, Rueda-Ochoa Oscar-Leonel, Sabanayagam Charumathi, Salako Babatunde L, Schreiner Pamela J, Shikany James M, Sidney Stephen S, Sims Mario, Sitlani Colleen M, Smith Jennifer A, Starr John M, Strauch Konstantin, Swertz Morris A, Teumer Alexander, Tham Yih Chung, Uitterlinden André G, Vaidya Dhananjay, van der Ende M Yldau, Waldenberger Melanie, Wang Lihua, Wang Ya-Xing, Wei Wen-Bin, Weir David R, Wen Wanqing, Yao Jie, Yu Bing, Yu Caizheng, Yuan Jian-Min, Zhao Wei, Zonderman Alan B, Becker Diane M, Bowden Donald W, Deary Ian J, Dörr Marcus, Esko Tõnu, Freedman Barry I, Froguel Philippe, Gasparini Paolo, Gieger Christian, Jonas Jost Bruno, Kammerer Candace M, Kato Norihiro, Lakka Timo A, Leander Karin, Lehtimäki Terho, Lifelines Cohort Study, Magnusson Patrik K E, Marques-Vidal Pedro, Penninx Brenda W J H, Samani Nilesh J, van der Harst Pim, Wagenknecht Lynne E, Wu Tangchun, Zheng Wei, Zhu Xiaofeng, Bouchard Claude, Cooper Richard S, Correa Adolfo, Evans Michele K, Gudnason Vilmundur, Hayward Caroline, Horta Bernardo L, Kelly Tanika N, Kritchevsky Stephen B, Levy Daniel, Palmas Walter R, Pereira A C, Province Michael M, Psaty Bruce M, Ridker Paul M, Rotimi Charles N, Tai E Shyong, van Dam Rob M, van Duijn Cornelia M, Wong Tien Yin, Rice Kenneth, Gauderman W James, Morrison Alanna C, North Kari E, Kardia Sharon L R, Caulfield Mark J, Elliott Paul, Munroe Patricia B, Franks Paul W, Rao Dabeeru C, Fornage Myriam
СтатьяМетаанализПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди
Аннотация
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects. Analyses were performed for systolic BP, diastolic BP, mean arterial pressure, and pulse pressure. We pursued genome-wide interrogation in Stage 1 studies (N = 117 438) and follow-up on promising variants in Stage 2 studies (N = 293 787) in five ancestry groups. Through combined meta-analyses of Stages 1 and 2, we identified 84 known and 18 novel BP loci at genome-wide significance level (P < 5 × 10-8). Two novel loci were identified based on the 1DF test of interaction with educational attainment, while the remaining 16 loci were identified through the 2DF joint test of genetic and interaction effects. Ten novel loci were identified in individuals of African ancestry. Several novel loci show strong biological plausibility since they involve physiologic systems implicated in BP regulation. They include genes involved in the central nervous system-adrenal signaling axis (ZDHHC17, CADPS, PIK3C2G), vascular structure and function (GNB3, CDON), and renal function (HAS2 and HAS2-AS1, SLIT3). Collectively, these findings suggest a role of educational attainment or SES in further dissection of the genetic architecture of BP.
Для цитирования: de las Fuentes Lisa, Sung Yun Ju, Noordam Raymond, Winkler Thomas, Feitosa Mary F, Schwander Karen, Bentley Amy R, Brown Michael R, Guo Xiuqing, Manning Alisa, Chasman Daniel I, Aschard Hugues, Bartz Traci M, Bielak Lawrence F, Campbell Archie, Cheng Ching-Yu, Dorajoo Rajkumar, Hartwig Fernando P, Horimoto A R V R, Li Changwei, Li-Gao Ruifang, Liu Yongmei, Marten Jonathan, Musani Solomon K, Ntalla Ioanna, Rankinen Tuomo, Richard Melissa, Sim Xueling, Smith Albert V, Tajuddin Salman M, Tayo Bamidele O, Vojinovic Dina, Warren Helen R, Xuan Deng, Alver Maris, Boissel Mathilde, Chai Jin-Fang, Chen Xu, Christensen Kaare, Divers Jasmin, Evangelou Evangelos, Gao Chuan, Girotto Giorgia, Harris Sarah E, He Meian, Hsu Fang-Chi, Kühnel Brigitte, Laguzzi Federica, Li Xiaoyin, Lyytikäinen Leo-Pekka, Nolte Ilja M, Poveda Alaitz, Rauramaa Rainer, Riaz Muhammad, Rueedi Rico, Shu Xiao-Ou, Snieder Harold, Sofer Tamar, Takeuchi Fumihiko, Verweij Niek, Ware Erin B, Weiss Stefan, Yanek Lisa R, Amin Najaf, Arking Dan E, Arnett Donna K, Bergmann Sven, Boerwinkle Eric, Brody Jennifer A, Broeckel Ulrich, Brumat Marco, Burke Gregory, Cabrera Claudia P, Canouil Mickaël, Chee Miao Li, Chen Yii-Der Ida, Cocca Massimiliano, Connell John, de Silva H Janaka, de Vries Paul S, Eiriksdottir Gudny, Faul Jessica D, Fisher Virginia, Forrester Terrence, Fox Ervin F, Friedlander Yechiel, Gao He, Gigante Bruna, Giulianini Franco, Gu Chi Charles, Gu Dongfeng, Harris Tamara B, He Jiang, Heikkinen Sami, Heng Chew-Kiat, Hunt Steven, Ikram M Arfan, Irvin Marguerite R, Kähönen Mika, Kavousi Maryam, Khor Chiea Chuen, Kilpeläinen Tuomas O, Koh Woon-Puay, Komulainen Pirjo, Kraja Aldi T, Krieger J E, Langefeld Carl D, Li Yize, Liang Jingjing, Liewald David C M, Liu Ching-Ti, Liu Jianjun, Lohman Kurt K, Mägi Reedik, McKenzie Colin A, Meitinger Thomas, Metspalu Andres, Milaneschi Yuri, Milani Lili, Mook-Kanamori Dennis O, Nalls Mike A, Nelson Christopher P, Norris Jill M, O'Connell Jeff, Ogunniyi Adesola, Padmanabhan Sandosh, Palmer Nicholette D, Pedersen Nancy L, Perls Thomas, Peters Annette, Petersmann Astrid, Peyser Patricia A, Polasek Ozren, Porteous David J, Raffel Leslie J, Rice Treva K, Rotter Jerome I, Rudan Igor, Rueda-Ochoa Oscar-Leonel, Sabanayagam Charumathi, Salako Babatunde L, Schreiner Pamela J, Shikany James M, Sidney Stephen S, Sims Mario, Sitlani Colleen M, Smith Jennifer A, Starr John M, Strauch Konstantin, Swertz Morris A, Teumer Alexander, Tham Yih Chung, Uitterlinden André G, Vaidya Dhananjay, van der Ende M Yldau, Waldenberger Melanie, Wang Lihua, Wang Ya-Xing, Wei Wen-Bin, Weir David R, Wen Wanqing, Yao Jie, Yu Bing, Yu Caizheng, Yuan Jian-Min, Zhao Wei, Zonderman Alan B, Becker Diane M, Bowden Donald W, Deary Ian J, Dörr Marcus, Esko Tõnu, Freedman Barry I, Froguel Philippe, Gasparini Paolo, Gieger Christian, Jonas Jost Bruno, Kammerer Candace M, Kato Norihiro, Lakka Timo A, Leander Karin, Lehtimäki Terho, Lifelines Cohort Study, Magnusson Patrik K E, Marques-Vidal Pedro, Penninx Brenda W J H, Samani Nilesh J, van der Harst Pim, Wagenknecht Lynne E, Wu Tangchun, Zheng Wei, Zhu Xiaofeng, Bouchard Claude, Cooper Richard S, Correa Adolfo, Evans Michele K, Gudnason Vilmundur, Hayward Caroline, Horta Bernardo L, Kelly Tanika N, Kritchevsky Stephen B, Levy Daniel, Palmas Walter R, Pereira A C, Province Michael M, Psaty Bruce M, Ridker Paul M, Rotimi Charles N, Tai E Shyong, van Dam Rob M, van Duijn Cornelia M, Wong Tien Yin, Rice Kenneth, Gauderman W James, Morrison Alanna C, North Kari E, Kardia Sharon L R, Caulfield Mark J, Elliott Paul, Munroe Patricia B, Franks Paul W, Rao Dabeeru C, Fornage Myriam. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.. Molecular psychiatry. 2020. DOI: 10.1038/s41380-020-0719-3.
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