Медицинская библиотека · Science (New York, N.Y.) · 2020
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Bastard Paul, Rosen Lindsey B, Zhang Qian, Michailidis Eleftherios, Hoffmann Hans-Heinrich, Zhang Yu, Dorgham Karim, Philippot Quentin, Rosain Jérémie, Béziat Vivien, Manry Jérémy, Shaw Elana, Haljasmägi Liis, Peterson Pärt, Lorenzo Lazaro, Bizien Lucy, Trouillet-Assant Sophie, Dobbs Kerry, de Jesus Adriana Almeida, Belot Alexandre, Kallaste Anne, Catherinot Emilie, Tandjaoui-Lambiotte Yacine, Le Pen Jeremie, Kerner Gaspard, Bigio Benedetta, Seeleuthner Yoann, Yang Rui, Bolze Alexandre, Spaan András N, Delmonte Ottavia M, Abers Michael S, Aiuti Alessandro, Casari Giorgio, Lampasona Vito, Piemonti Lorenzo, Ciceri Fabio, Bilguvar Kaya, Lifton Richard P, Vasse Marc, Smadja David M, Migaud Mélanie, Hadjadj Jérome, Terrier Benjamin, Duffy Darragh, Quintana-Murci Lluis, van de Beek Diederik, Roussel Lucie, Vinh Donald C, Tangye Stuart G, Haerynck Filomeen, Dalmau David, Martinez-Picado Javier, Brodin Petter, Nussenzweig Michel C, Boisson-Dupuis Stéphanie, Rodríguez-Gallego Carlos, Vogt Guillaume, Mogensen Trine H, Oler Andrew J, Gu Jingwen, Burbelo Peter D, Cohen Jeffrey I, Biondi Andrea, Bettini Laura Rachele, D'Angio Mariella, Bonfanti Paolo, Rossignol Patrick, Mayaux Julien, Rieux-Laucat Frédéric, Husebye Eystein S, Fusco Francesca, Ursini Matilde Valeria, Imberti Luisa, Sottini Alessandra, Paghera Simone, Quiros-Roldan Eugenia, Rossi Camillo, Castagnoli Riccardo, Montagna Daniela, Licari Amelia, Marseglia Gian Luigi, Duval Xavier, Ghosn Jade, HGID Lab, NIAID-USUHS Immune Response to COVID Group, COVID Clinicians, COVID-STORM Clinicians, Imagine COVID Group, French COVID Cohort Study Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank, COVID Human Genetic Effort, Tsang John S, Goldbach-Mansky Raphaela, Kisand Kai, Lionakis Michail S, Puel Anne, Zhang Shen-Ying, Holland Steven M, Gorochov Guy, Jouanguy Emmanuelle, Rice Charles M, Cobat Aurélie, Notarangelo Luigi D, Abel Laurent, Su Helen C, Casanova Jean-Laurent
СтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАПеревод в очереди
Аннотация
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Для цитирования: Bastard Paul, Rosen Lindsey B, Zhang Qian, Michailidis Eleftherios, Hoffmann Hans-Heinrich, Zhang Yu, Dorgham Karim, Philippot Quentin, Rosain Jérémie, Béziat Vivien, Manry Jérémy, Shaw Elana, Haljasmägi Liis, Peterson Pärt, Lorenzo Lazaro, Bizien Lucy, Trouillet-Assant Sophie, Dobbs Kerry, de Jesus Adriana Almeida, Belot Alexandre, Kallaste Anne, Catherinot Emilie, Tandjaoui-Lambiotte Yacine, Le Pen Jeremie, Kerner Gaspard, Bigio Benedetta, Seeleuthner Yoann, Yang Rui, Bolze Alexandre, Spaan András N, Delmonte Ottavia M, Abers Michael S, Aiuti Alessandro, Casari Giorgio, Lampasona Vito, Piemonti Lorenzo, Ciceri Fabio, Bilguvar Kaya, Lifton Richard P, Vasse Marc, Smadja David M, Migaud Mélanie, Hadjadj Jérome, Terrier Benjamin, Duffy Darragh, Quintana-Murci Lluis, van de Beek Diederik, Roussel Lucie, Vinh Donald C, Tangye Stuart G, Haerynck Filomeen, Dalmau David, Martinez-Picado Javier, Brodin Petter, Nussenzweig Michel C, Boisson-Dupuis Stéphanie, Rodríguez-Gallego Carlos, Vogt Guillaume, Mogensen Trine H, Oler Andrew J, Gu Jingwen, Burbelo Peter D, Cohen Jeffrey I, Biondi Andrea, Bettini Laura Rachele, D'Angio Mariella, Bonfanti Paolo, Rossignol Patrick, Mayaux Julien, Rieux-Laucat Frédéric, Husebye Eystein S, Fusco Francesca, Ursini Matilde Valeria, Imberti Luisa, Sottini Alessandra, Paghera Simone, Quiros-Roldan Eugenia, Rossi Camillo, Castagnoli Riccardo, Montagna Daniela, Licari Amelia, Marseglia Gian Luigi, Duval Xavier, Ghosn Jade, HGID Lab, NIAID-USUHS Immune Response to COVID Group, COVID Clinicians, COVID-STORM Clinicians, Imagine COVID Group, French COVID Cohort Study Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank, COVID Human Genetic Effort, Tsang John S, Goldbach-Mansky Raphaela, Kisand Kai, Lionakis Michail S, Puel Anne, Zhang Shen-Ying, Holland Steven M, Gorochov Guy, Jouanguy Emmanuelle, Rice Charles M, Cobat Aurélie, Notarangelo Luigi D, Abel Laurent, Su Helen C, Casanova Jean-Laurent. Autoantibodies against type I IFNs in patients with life-threatening COVID-19.. Science (New York, N.Y.). 2020. DOI: 10.1126/science.abd4585.
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