The effect of histamine on the induction of experimental autoimmune hemolytic anemia on OF1, BALB/c and SJL mice.

Erythrocyte autoantibodies can be elicited in mice by injection of rat red blood cells (RBC) which are cross-reactive with mouse RBC. In this report, we show that histamine injected in vivo delayed the production of autoantibodies among BALB/c and OF1 mice. In contrast, the induction of autoantibodies in SJL mice was not affected by histamine. Furthermore, histamine did not affect the production of anti-rat RBC. Cimetidine (anti-H2) but not diphenhydramine (anti-H1) inhibited the histamine effect.