The Contribution and Importance of Animal Research to HIV Prevention in the United States.

Nonhuman primate research has been critical for the advancement of human immunodeficiency virus (HIV) prevention, including the development of preexposure prophylaxis. Many studies have been conducted by or in partnership with the Centers for Disease Control and Prevention (CDC) and/or the National Institutes of Health. In November 2025, scientists at the CDC were notified that studies involving animal research and specifically nonhuman primate research were being eliminated. These and other efforts to eliminate nonhuman primate research will have serious consequences in the field of HIV prevention and will hamper future efforts to develop and evaluate HIV prevention approaches including preexposure prophylaxis.