Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 1996
Androstenedione aromatization as a cause of gynecomastia in 11beta-hydroxylase and 21-hydroxylase deficiencies.
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Blackett MD P R, Freeman MD D A
Аннотация
OBJECTIVE: To report two cases of gynecomastia that occurred in boys with 11beta-hydroxylase and 21-hydroxylase deficiency.
METHODS: We describe the physical findings and summarize the laboratory evaluation and treatment of two cases encountered in our medical practice.
RESULTS: Both of our patients (a 4-year-old boy and a 17-year-old boy) had extreme virilization and gynecomastia; on laboratory assessment, androstenedione and estrogen levels were high. Treatment with hydrocortisone was recommended.
CONCLUSION: Peripheral conversion of adrenal androgen to estrogen likely caused the feminizing syndrome in these patients.
METHODS: We describe the physical findings and summarize the laboratory evaluation and treatment of two cases encountered in our medical practice.
RESULTS: Both of our patients (a 4-year-old boy and a 17-year-old boy) had extreme virilization and gynecomastia; on laboratory assessment, androstenedione and estrogen levels were high. Treatment with hydrocortisone was recommended.
CONCLUSION: Peripheral conversion of adrenal androgen to estrogen likely caused the feminizing syndrome in these patients.