[Familial hydatidiform mole syndrome and genetic aspects of this disturbed trophoblast development].

A female sibship is presented, where in a total of six sisters aged 16 to 34 years three women suffered from recurrent hydatiform molar pregnancies. Until now none of them has given birth to a child. The family's pedigree and the seven molar events are shown, and cytogenetic findings of complete and incomplete (partial) hydatiform mole as described in the literature and with regard to histomorphological changes. Finally, "genomic imprinting" means that it makes a difference whether chromosomes are derived maternally or paternally (parental origin effect).