American journal of obstetrics and gynecology · 1996
Cocaine's effect on plasma oxytocin concentrations in the baboon during late pregnancy.
СтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Morgan M A, Honnebier M B, Mecenas C, Nathanielsz P W
Аннотация
OBJECTIVE: The hypothesis for this investigation was that intravenous cocaine would result in an elevation of maternal plasma oxytocin levels in the baboon during late pregnancy.
STUDY DESIGN: Five gravid chronically instrumented baboons had timed arterial blood samples obtained before and after an intravenous bolus cocaine infusion at least 5 days after surgery. Plasma oxytocin concentrations were measured by specific radioimmunoassays, and baseline samples were compared with postcocaine samples.
RESULTS: The plasma oxytocin concentrations were significantly elevated at all sampling times after the 1.0 mg/kg cocaine dose (p<0.05).
CONCLUSION: The increased oxytocin concentration after cocaine use may be responsible for the increased incidence of preterm labor.
STUDY DESIGN: Five gravid chronically instrumented baboons had timed arterial blood samples obtained before and after an intravenous bolus cocaine infusion at least 5 days after surgery. Plasma oxytocin concentrations were measured by specific radioimmunoassays, and baseline samples were compared with postcocaine samples.
RESULTS: The plasma oxytocin concentrations were significantly elevated at all sampling times after the 1.0 mg/kg cocaine dose (p<0.05).
CONCLUSION: The increased oxytocin concentration after cocaine use may be responsible for the increased incidence of preterm labor.