Australian and New Zealand journal of ophthalmology · 1998
Outcomes of cytomegalovirus retinitis following the use of ganciclovir implants.
СтатьяНазвание и аннотация: Перевод в очереди
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McCluskey P J, Shah R, Versace P
Аннотация
PURPOSE: To determine the results and complications from the use of ganciclovir implants to treat patients with HIV infection and cytomegalovirus (CMV) retinitis.
METHODS: The present study was a retrospective review of 87 consecutive ganciclovir implant surgeries performed in 60 patients over a 3 year period.
RESULTS: Based on the results of the present study, ganciclovir implants are an efficacious therapy for CMV retinitis but are associated with significant postoperative complications, including retinal detachment (12.0%), vitreous haemorrhage (7.2%) and cataract formation (6.0%). In this series, all implanted eyes responded to treatment and the mean time to progression was 252 days. Only a small number of patients developed second eye involvement (n = 9) or clinically significant CMV infection of other organ systems (n = 5).
CONCLUSIONS: This small retrospective study provides additional data confirming the effectiveness of ganciclovir implants and the complications from their use.
METHODS: The present study was a retrospective review of 87 consecutive ganciclovir implant surgeries performed in 60 patients over a 3 year period.
RESULTS: Based on the results of the present study, ganciclovir implants are an efficacious therapy for CMV retinitis but are associated with significant postoperative complications, including retinal detachment (12.0%), vitreous haemorrhage (7.2%) and cataract formation (6.0%). In this series, all implanted eyes responded to treatment and the mean time to progression was 252 days. Only a small number of patients developed second eye involvement (n = 9) or clinically significant CMV infection of other organ systems (n = 5).
CONCLUSIONS: This small retrospective study provides additional data confirming the effectiveness of ganciclovir implants and the complications from their use.