Current allergy and asthma reports · 2026
Inverted Sinonasal Papilloma: Pheno-endotyping and Predictive Markers of Recurrence and Malignancy - A Systematic Review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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Aguilera María Paola, Pastene Daniela, Lop Joan, Marin Concepció, Mullol Joaquim, Alobid Isam
Аннотация
PURPOSE OF REVIEW: This review aimed to summarize the inflammatory, microscopic, and histopathological features of inverted sinonasal papilloma (ISP) and to identify viral, molecular, and genetic predictors of recurrence and malignant transformation.
RECENT FINDINGS: Recent studies describe a heterogeneous inflammatory microenvironment with mixed Th1/Th2/Th17 cytokine responses and epithelial neutrophilia as a defining hallmark. Considerable variability persists across studies evaluating viral and molecular markers. High-risk Human Papillomavirus type 18 (HR-HPV-18), Epidermal Growth Factor Receptor (EGFR) exon 20 mutations, p53 alterations, and p16 loss have been most consistently linked to recurrence and malignant progression. SNIP exhibits multifactorial biological behavior driven by inflammation, viral infection, and molecular dysregulation. These findings highlight the need for standardized histopathological and molecular criteria and prospective studies to refine recurrence prediction and early detection of malignant transformation.
RECENT FINDINGS: Recent studies describe a heterogeneous inflammatory microenvironment with mixed Th1/Th2/Th17 cytokine responses and epithelial neutrophilia as a defining hallmark. Considerable variability persists across studies evaluating viral and molecular markers. High-risk Human Papillomavirus type 18 (HR-HPV-18), Epidermal Growth Factor Receptor (EGFR) exon 20 mutations, p53 alterations, and p16 loss have been most consistently linked to recurrence and malignant progression. SNIP exhibits multifactorial biological behavior driven by inflammation, viral infection, and molecular dysregulation. These findings highlight the need for standardized histopathological and molecular criteria and prospective studies to refine recurrence prediction and early detection of malignant transformation.