Establishment of a Patient-Derived Xenograft Model of a Testicular Yolk Sac Tumor.

We have established a highly stable and reproducible patient derived xenograft model that exclusively and robustly retains the morphological, functional, and proliferative characteristics of human yolk sac tumor of the testis. This model might provide an invaluable in vivo platform for accelerating the discovery and validation of novel therapeutic strategies for this aggressive malignancy, with the ultimate aim of improving the prognosis for affected patients.