A discrete nonlinear model for HPV immune suppression and evasion.

In this paper we present a nonlinear discrete model in order to describe defective interactions of immune system cells with Human Papillomavirus (HPV) infected cells. Statistics show than only a percentage of the HPV infected population will develop malignancy diseases. Our goal is to develop a prototypical mathematical model that is analitically tratable with a statistical complexity to reproduce qualitative and quantitative information of the consequences of HPV-evasion of host defenses and suppression of an efficient immune response. Numerical results obtained from the model confirm the intrinsic relationships of its nonlinear terms representing the earlier evolution of mature infected cells with a successful virus invasion.