Infections After Kidney Transplantation From Donors With HIV to Recipients With HIV.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Arant Elizabeth C, Davy-Mendez Thibaut, Liang Tao, Rodrigues Moreno, Gay Cynthia L, Rana Meenakshi M, Friedman-Moraco Rachel, Gilbert Alexander, Stock Peter, Mehta Sapna A, Mehta Shikha, Stosor Valentina, Pereira Marcus R, Morris Michele I, Hand Jonathan, Aslam Saima, Malinis Maricar, Haidar Ghady, Small Catherine B, Santos Carlos A Q, Schaenman Joanna, Baddley John W, Wojciechowski David, Blumberg Emily A, Ranganna Karthik, Adebiyi Oluwafisayo, Elias Nahel, Castillo-Lugo Jose A, Giorgakis Emmanouil, Apewokin Senu, Morsheimer Megan, van Delden Christian, Manuel Oriol, Mueller Nicolas J, Neofyotos Dionysios, Tobian Aaron A R, Massie Allan, Segev Dorry L, Werbel William, Durand Christine M
Аннотация
METHODS: We performed a secondary analysis of the HOPE in Action KT Study (NCT02602262) comparing the time to first clinically relevant infection within 24 months posttransplantation in 99 HIV D+/R+ versus 99 HIV D-/R+. Secondary outcomes included incidence rates, infection-related death, and timing of clinically relevant infection, each stratified by donor HIV status.
RESULTS: The cumulative incidence of a clinically relevant infection at 24 months posttransplantation was 73.8% (95% confidence interval [CI]: 63.1%-81.2%) for HIV D+/R+ versus 64.7% (95% CI: 53.0%-73.4%) for HIV D-/R+. Comparing time to first clinically relevant infection in HIV D+/R+ versus HIV D-/R+, the adjusted hazard ratio (aHR) was 1.44 (95% CI: 1.01-2.04) at 24 months posttransplantation; for infections associated with hospitalization, the aHR was not significantly higher (1.21 [95% CI: .78-1.86). There were no significant differences in the number of infections, death from infection, duration, or site of infection between HIV D+/R+ versus HIV D-/R+, though viral infections were numerically more common in HIV D+/R+ (40% vs 35%).
CONCLUSIONS: Although there was a statistically significant association between receipt of a kidney from a donor with HIV and time to first clinically relevant infection in the 24 months posttransplantation, there were no differences in infections associated with hospitalization. These data are overall reassuring as this emerging practice expands into clinical care. Clinical Trials Registration. NCT02602262.