Novel Arylamine-Type Terpenoid and Isoflavone Isolated From a Marine Aspergillus Strain.

Marine fungi are known to produce natural products possessing significant therapeutic potential. Here, chemical exploration of a marine-derived Aspergillus strain, coupled with comprehensive spectroscopic analyses (NMR spectroscopy and x-ray diffraction) and chemical calculations, resulted in the isolation and identification of six aryl-type compounds, including three new metabolites: aspergiterpenamine (1), norbisaboid (3), and 3'-carboxy-4',7-dihydroxyisoflavone (4). Notably, compound 1 features an unprecedented benzylamine moiety fused to a bisabolane sesquiterpene scaffold, while compound 3 is distinguished by the elimination of three carbons from the isopropyl side chain of its terpene skeleton, which expands the structural diversity of aryl-containing natural products.