Biomarkers in medicine · 2025
Triglyceride-glucose index as a novel biomarker for mild cognitive impairment in patients with coronary artery disease.
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Feng Lanxin, Li Jianan, Zhao Xin, Song Jianqiao, Yang Shuwen, Wang Xiaoyi, Liu Chenyang, Zhang Min, Tu Chenchen, Song Xiantao
Аннотация
BACKGROUND: Patients with coronary artery disease (CAD) are at an increased risk of cognitive impairment, yet reliable noninvasive biomarkers for identifying high-risk individuals in this population remain scarce. This study aimed to investigate the association between the triglyceride-glucose (TyG) index and cognitive function in patients with CAD.
METHODS: This study included 1163 patients with CAD who underwent cognitive function assessment. Multiple regression analyses were conducted to evaluate the relationship between the TyG index and cognitive function. Furthermore, receiver operating characteristic (ROC) curve analysis was conducted to determine the discriminatory ability of the TyG index in identifying patients with mild cognitive impairment (MCI).
RESULTS: The TyG index was negatively correlated with Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) scores (r = -0.16, p < 0.001 and r = -0.33, p < 0.001, respectively). Specifically, when the TyG index was ≥8.72, higher values were associated with increased risk of MCI (OR: 3.69, 95% CI: 2.12, 6.58). ROC analysis revealed that the optimal cutoff value for the TyG index was 8.906 (specificity: 73.8%, sensitivity: 60.2%).
CONCLUSION: The TyG index is independently associated with cognitive function in patients with CAD, with elevated values associated with an increased risk of MCI.
METHODS: This study included 1163 patients with CAD who underwent cognitive function assessment. Multiple regression analyses were conducted to evaluate the relationship between the TyG index and cognitive function. Furthermore, receiver operating characteristic (ROC) curve analysis was conducted to determine the discriminatory ability of the TyG index in identifying patients with mild cognitive impairment (MCI).
RESULTS: The TyG index was negatively correlated with Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) scores (r = -0.16, p < 0.001 and r = -0.33, p < 0.001, respectively). Specifically, when the TyG index was ≥8.72, higher values were associated with increased risk of MCI (OR: 3.69, 95% CI: 2.12, 6.58). ROC analysis revealed that the optimal cutoff value for the TyG index was 8.906 (specificity: 73.8%, sensitivity: 60.2%).
CONCLUSION: The TyG index is independently associated with cognitive function in patients with CAD, with elevated values associated with an increased risk of MCI.