[Analysis of mpox cases co-infected with HIV in Zhejiang Province].

Objective

To analyze the epidemiological characteristics of mpox cases co-infected with HIV in Zhejiang Province and to provide a reference basis for formulating multi-disease co-prevention strategies for key populations.

Methods

The data are derived from the mpox cases and HIV-infected individuals reported in Zhejiang Province from June 1, 2023 to December 31, 2024 in the Chinese Information System for Disease Control and Prevention. The data of mpox cases combined with HIV infection were matched through identity information. Descriptive epidemiological methods were used to analyze the basic characteristics of the cases, and chi-square test and Fisher's exact probability method were used to compare the differences between groups. Data cleaning and statistical analysis were conducted using Excel 2020 sofware and R 4.5.0. sofware

Results

From June 2023 to December 31,2024, a total of 233 cases of mpox were reported in Zhejiang Province, among which 93 cases (39.9%) were co-infected with HIV, all of whom were men who had sex with men (MSM), and 2 deaths occurred. From June to December in 2023, 44.3% (81/183) of mpox cases were co-infected with HIV, which was higher than that in 2024 (24.0%,12/50), and the difference was statistically significant (χ2=6.72,P=0.010). Among those co-infected with HIV,the proportion of previously reported and newly reported HIV-infected individuals was 82.8% (77/93) and 17.2% (16/93), respectively. The difference in the viral load of the most recent HIV infection between previously reported and newly reported HIV-infected individuals was statistically significant (P=0.001).

Conclusions

From June 2023 to December 2024, the proportion of cases of mpox who were co-infected with HIV was relatively high, and all of them were MSM in Zhejiang Province. It is recommended to strengthen the coordinated prevention and control of mpox virus and HIV for this population, and implement precise intervention measures such as publicity and education, behavioral intervention, and treatment and management of HIV-infected cases.