International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2025
Prevalence and Correlates of metabolic syndrome among people living with HIV receiving dolutegravir-based ART in Northwest Ethiopia: A cross-sectional study.
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Jemal Mohammed, Adugna Adane, Abebaw Desalegn, Malik Tabarak, Ashenef Baye, Baye Gelagey, Kindie Yonatan, Mihiret Getachew Tilaye, Baylie Temesgen, Waritu Nuredin Chura, Osman Enatnesh Essa, Belay Wubetu Yihunie, Rike Mohammed Ebrahim, Mengistu Enyew Fenta
Аннотация
OBJECTIVES: Antiretroviral therapy (ART) has been associated with components of metabolic syndrome (MetS), including glucose intolerance, weight gain, and dyslipidemia. However, with the advent of newer agents such as dolutegravir (DTG), evidence on the burden of MetS remains limited. Therefore, this study aimed to assess the prevalence of MetS and its determinants among people living with HIV (PLWH) receiving DTG-based ART at Debre Markos Comprehensive Specialized Hospital (DMCSH), Northwest Ethiopia.
METHODS: An institution-based cross-sectional study was conducted from December 1, 2021, to February 28, 2022, among 422 randomly selected participants using face-to-face interviews, anthropometric assessments, medical chart reviews, and biochemical measurements. MetS was defined based on the 2009 harmonized criteria. Epi-Data version 4.6 and SPSS version 26 were used for data entry and statistical analysis, respectively. Bivariable and multivariable logistic regression analyses were employed to identify factors associated with MetS. A statistical significance was decided at P ≤ 0.05.
RESULTS: The prevalence of MetS was 27.7% (95% CI: 23.7-32.2), with reduced high-density lipoprotein cholesterol (60.9%) was the most prevalent component. In adjusted analysis, alcohol use (AOR: 1.92; 95% CI: 1.02-3.6), inadequate physical activity (AOR: 1.7; 95% CI: 1.08-2.67), body mass index (BMI) ≥ 25 kg/m2 (AOR: 1.75; 95% CI: 1.1-2.76), and CD4+ T-cell count ≥500 cell/mm3 (AOR: 1.73; 95% CI: 1.1-2.73) were significantly associated with MetS.
CONCLUSION: Overall, our study showed that MetS (27.7%) was relatively common among PLWH receiving DTG-based ART. Alcohol use, inadequate physical activity, BMI ≥25 kg/m2, and CD4 T-cell count ≥500 cell/mm3 were significantly associated with MetS. Routine clinical monitoring and assessment of all MetS components are recommended for PLWH receiving DTG-based ART, with particular attention to those who consume alcohol, have inadequate physical activity, elevated BMI, or higher CD4+ T-cell count.
METHODS: An institution-based cross-sectional study was conducted from December 1, 2021, to February 28, 2022, among 422 randomly selected participants using face-to-face interviews, anthropometric assessments, medical chart reviews, and biochemical measurements. MetS was defined based on the 2009 harmonized criteria. Epi-Data version 4.6 and SPSS version 26 were used for data entry and statistical analysis, respectively. Bivariable and multivariable logistic regression analyses were employed to identify factors associated with MetS. A statistical significance was decided at P ≤ 0.05.
RESULTS: The prevalence of MetS was 27.7% (95% CI: 23.7-32.2), with reduced high-density lipoprotein cholesterol (60.9%) was the most prevalent component. In adjusted analysis, alcohol use (AOR: 1.92; 95% CI: 1.02-3.6), inadequate physical activity (AOR: 1.7; 95% CI: 1.08-2.67), body mass index (BMI) ≥ 25 kg/m2 (AOR: 1.75; 95% CI: 1.1-2.76), and CD4+ T-cell count ≥500 cell/mm3 (AOR: 1.73; 95% CI: 1.1-2.73) were significantly associated with MetS.
CONCLUSION: Overall, our study showed that MetS (27.7%) was relatively common among PLWH receiving DTG-based ART. Alcohol use, inadequate physical activity, BMI ≥25 kg/m2, and CD4 T-cell count ≥500 cell/mm3 were significantly associated with MetS. Routine clinical monitoring and assessment of all MetS components are recommended for PLWH receiving DTG-based ART, with particular attention to those who consume alcohol, have inadequate physical activity, elevated BMI, or higher CD4+ T-cell count.