Thrombosis research · 2014
Fibrinogen levels in the late stage of twin pregnancy.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Yamada Takashi, Morikawa Mamoru, Yamada Takahiro, Akaishi Rina, Kojima Takashi, Minakami Hisanori
Аннотация
INTRODUCTION: Twin pregnancy is a risk factor of complications, such as pregnancy-induced hypertension, venous thromboembolism, and postpartum hemorrhage, the pathogenesis of which may involve aberrations of the coagulation-fibrinolysis system.
MATERIALS AND METHODS: Fibrinogen data for 129 and 1202 blood specimens from 84 and 902 women with twin and singleton pregnancies, respectively, at gestational week (GW)≥32 were analyzed retrospectively. None of the 986 women developed complications in which blood fibrinogen levels may be altered. Thirty-six and 288 women with twin and singleton pregnancies were examined longitudinally, respectively.
RESULTS: The fibrinogen levels of 403±63 and 403±77 mg/dL at GW 32-33 and 34-35, respectively, decreased significantly to 366±57 mg/dL at GW 36-37 in women with twins, while corresponding levels (422±79, 420±65, and 415±64, respectively) and that at GW≥38 (408±60 mg/dL) did not change significantly in women with singleton pregnancies. The fibrinogen levels determined within 3 weeks before delivery were consistently and significantly lower in women with twin than singleton pregnancies. The fibrinogen levels were significantly inversely correlated with GW in women with twins (R=-0.36, P=0.002), but not in those with singleton pregnancies.
CONCLUSIONS: The fibrinogen level of twin pregnancy decreases significantly and is significantly lower than that in singleton pregnancy in the last few weeks of pregnancy.
MATERIALS AND METHODS: Fibrinogen data for 129 and 1202 blood specimens from 84 and 902 women with twin and singleton pregnancies, respectively, at gestational week (GW)≥32 were analyzed retrospectively. None of the 986 women developed complications in which blood fibrinogen levels may be altered. Thirty-six and 288 women with twin and singleton pregnancies were examined longitudinally, respectively.
RESULTS: The fibrinogen levels of 403±63 and 403±77 mg/dL at GW 32-33 and 34-35, respectively, decreased significantly to 366±57 mg/dL at GW 36-37 in women with twins, while corresponding levels (422±79, 420±65, and 415±64, respectively) and that at GW≥38 (408±60 mg/dL) did not change significantly in women with singleton pregnancies. The fibrinogen levels determined within 3 weeks before delivery were consistently and significantly lower in women with twin than singleton pregnancies. The fibrinogen levels were significantly inversely correlated with GW in women with twins (R=-0.36, P=0.002), but not in those with singleton pregnancies.
CONCLUSIONS: The fibrinogen level of twin pregnancy decreases significantly and is significantly lower than that in singleton pregnancy in the last few weeks of pregnancy.