Tremor and other hyperkinetic movements (New York, N.Y.) · 2023
Task Specific Tremor in Parkinson's Disease Responds to Apomorphine.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ondo William G, Koneru Vindhya, Arif Chia
Аннотация
BACKGROUND: Task specific tremor (TST) is a poorly understood entity without any standard treatments, that may subsequently develop tremor during additional tasks, later develop postural/kinetic tremor (essential tremor criteria), and later develop Parkinson's disease. The pathophysiology is not understood as it has features of tremor, dystonia, and parkinsonism.
OBJECTIVES: To assess response of TST to apomorphine and thus infer pathophysiology.
METHODS: We administered sublingual apomorphine to 8 patients diagnosed with Parkinson's disease based on clinical criteria and dopamine imaging, who all initially presented with TST and later presented other parkinsonian signs and dopamine imaging deficits.
RESULTS: Apomorphine improved TST, which was refractory to oral levodopa and other tremor therapies, in 6/8 subjects.
DISCUSSION: These results offer a treatment option for TST, which is usually refractory to other pharmacologic treatments, in patients with other parkinsonian features, and infers a dopaminergic pathophysiology of TST.
OBJECTIVES: To assess response of TST to apomorphine and thus infer pathophysiology.
METHODS: We administered sublingual apomorphine to 8 patients diagnosed with Parkinson's disease based on clinical criteria and dopamine imaging, who all initially presented with TST and later presented other parkinsonian signs and dopamine imaging deficits.
RESULTS: Apomorphine improved TST, which was refractory to oral levodopa and other tremor therapies, in 6/8 subjects.
DISCUSSION: These results offer a treatment option for TST, which is usually refractory to other pharmacologic treatments, in patients with other parkinsonian features, and infers a dopaminergic pathophysiology of TST.