Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa.

OBJECTIVE

Recovery from anorexia nervosa is confounded by intrusive anorectic cognitions and rituals. It has been observed that olanzapine, an atypical antipsychotic, can reduce this anorexic rumination. A pilot study was designed to test the effectiveness of olanzapine in this role.

METHODS

A randomized trial of olanzapine versus chlorpromazine, with anorexic rumination as the primary outcome, was conducted. Of the 26 patients who presented, 15 were randomized in a balanced block design, eight to olanzapine and seven to chlorpromazine.

RESULTS

Only the olanzapine group had a significant reduction in the degree of rumination.

CONCLUSION

Olanzapine may be of benefit in anorexia nervosa by causing a reduction in anorexic rumination.