The Erosion of a Pillar of Public Health: ACIP's Role and the Future of US Vaccine Policy Post-June 2025.

Since June 2025, the restructuring of the US Advisory Committee on Immunization Practices (ACIP)-including the abrupt replacement of all voting members and leadership-marked a significant departure from its longstanding norms of continuity and governance. Subsequent deviations from evidence-based policymaking raise concerns about the independence, transparency, and scientific rigor of vaccine policies under the new Department of Health and Human Services administration. The politicization of deliberations, selective use of questionable evidence, and disregard for established methodological standards threaten to undermine vaccine development, access, and public trust. Potential consequences include diminished credibility of federal vaccine recommendations, reduced advisory capacity for advancing key and new vaccines (eg, cytomegalovirus, Lyme disease), and disruption of critical and leading research infrastructure. Safeguarding ACIP's integrity through legislative and structural reforms is essential to restoring its credibility, preserving US leadership in global vaccine science, and maintaining population protection through robust, evidence-based immunization policy.