Fabrication of nano-ceria encapsulated with oleic acid to attenuate gestational diabetes mellitus in streptozotocin-induced diabetic pregnant mice model.

AIM: The study aims to fabricate and evaluate Nano-ceria encapsulated oleic acid (CeO2 NPs-OA) to treat gestational diabetes mellitus (GDM).

METHODS

The CeO2 NPs was synthesised by thermal decomposition. TEM, XRD, and FTIR confirms particles. In vitro studies on STZ-induced NIH 3T3 assessed antioxidant, anticancer, antidiabetic, and anti-inflammatory properties. In vivo studies were performed on pregnant mice induced with STZ, examined antidiabetic activity, oxidative stress, and dyslipidemia.

RESULTS

The CeO2 NPs-OA had a spherical structure and uniform distribution. A PDI of 0.5 with a zeta-potential of - 44 ± 2 mV. The DPPH and ABTS exhibit 40% and 39.21% antioxidant activity. The CeO2 NPs-OA inhibits diabetes at 500 μg/mL. The in vivo studies confirmed the reduction in oxidative stress by reducing MDA (p < 0.05). The histopathological analysis of the STZ-induced model shows capillary, which CeO2 NPs-OA reduced.

CONCLUSION

CeO2 NPs-OA shows promise for treating GDM and improving maternal and foetal health.