Fertility and sterility · 2013
Continuous versus cyclic use of oral contraceptives after surgery for symptomatic endometriosis: a prospective cohort study.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Vlahos Nikos, Vlachos Athanasios, Triantafyllidou Olga, Vitoratos Nikolaos, Creatsas George
Аннотация
OBJECTIVE: To evaluate the efficacy of continuous oral contraceptive (OC) use versus the usual cyclic fashion in the recurrence of endometriosis-related symptoms after surgery.
DESIGN: Prospective cohort trial involving patients in two tertiary care units.
SETTING: Academic institution in collaboration with a private hospital.
PATIENT(S): 356 patients underwent surgical treatment by laparoscopy for symptomatic endometriosis.
INTERVENTION(S): After surgical treatment for endometriosis, patients offered 6-month course of cyclic OC (including a 7-day pill-free period) or continuous OC.
MAIN OUTCOME MEASURE(S): Recurrence rate of endometriosis-related symptoms and endometriomas after fertility-sparing surgery.
RESULT(S): Out of 356 patients, 167 were placed on the usual cyclic OC course and 85 on continuous OC for a minimum of 6 months. The continuous OC group experienced a statistically significant reduction in recurrence rates for endometrioma, dysmenorrhea, and non-menstrual pelvic pain as compared with the cyclic OC group. There was no reduction in the recurrence of dyspareunia between the two groups.
CONCLUSION(S): After surgical treatment of endometriosis, the use of both cyclic and continuous OC improves pain symptoms when compared with preoperative scores. Continuous OC appears to be associated with a reduced recurrence rate for dysmenorrhea, non-menstrual pelvic pain, and endometrioma but not for dyspareunia as compared with cyclic OC.
DESIGN: Prospective cohort trial involving patients in two tertiary care units.
SETTING: Academic institution in collaboration with a private hospital.
PATIENT(S): 356 patients underwent surgical treatment by laparoscopy for symptomatic endometriosis.
INTERVENTION(S): After surgical treatment for endometriosis, patients offered 6-month course of cyclic OC (including a 7-day pill-free period) or continuous OC.
MAIN OUTCOME MEASURE(S): Recurrence rate of endometriosis-related symptoms and endometriomas after fertility-sparing surgery.
RESULT(S): Out of 356 patients, 167 were placed on the usual cyclic OC course and 85 on continuous OC for a minimum of 6 months. The continuous OC group experienced a statistically significant reduction in recurrence rates for endometrioma, dysmenorrhea, and non-menstrual pelvic pain as compared with the cyclic OC group. There was no reduction in the recurrence of dyspareunia between the two groups.
CONCLUSION(S): After surgical treatment of endometriosis, the use of both cyclic and continuous OC improves pain symptoms when compared with preoperative scores. Continuous OC appears to be associated with a reduced recurrence rate for dysmenorrhea, non-menstrual pelvic pain, and endometrioma but not for dyspareunia as compared with cyclic OC.
Предметные рубрики MeSH
AdultChi-Square DistributionContraceptives, Oral, HormonalContraceptives, Oral, SequentialDrug Administration ScheduleDysmenorrheaEndometriosisFemaleFertility PreservationGreeceHumansKaplan-Meier EstimateLaparoscopyPostoperative PainPelvic PainPostoperative CareProspective StudiesRecurrenceTertiary Care CentersTime FactorsTreatment Outcome