Discrepancies between ESTRO/ESGO/SIOPE and NCCN guidelines in the management of vaginal cancer: a call for harmonization.

Current vaginal cancer guidelines need refining. First of all: Cancer can only be called vaginal if there is no cervical or vulval involvement or in case of a prior anogenital cancer were the HPV type(s) between the cancers are different. Secondly: Surgery, accompanied by SLN mapping, should be the first-line treatment for early-stage vaginal cancer. Thirdly: HPV testing and typing should be part of both pretreatment evaluation and follow-up.