Preliminary study of the biodegradation and the correlation between in vitro and in vivo release of (32)P-chromic phosphate-poly(L-lactide) seeds.

OBJECTIVE

To investigate the drug release kinetic of (32)P-chromic phosphate-poly(L-lactide) ((32)P-CP-PLLA).

METHODS

(32)P-CP-PLLA were placed into physiological saline and H22 solid tumor mass, respectively. The weight loss rate and radioactivity release rate were evaluated. The release of the microparticles was evaluated using fitting curves. The correlation of the release of the microparticles between physiological saline and H22 solid tumor mass was analyzed.

RESULTS

Close correlation was noted in the release of the microparticles between physiological saline and H22 solid tumor mass. The Weibull equation showed the best fitting of (32)P-CP-PLLA in physiological saline.

CONCLUSIONS

The Weibull equation could be used for the predictive release of microparticles in vitro. The parameters obtained from the drug release kinetics could be used to estimate the dose of radiopharmaceuticals within the tumors and the surrounding tissues.