Journal of reproductive immunology · 2005
Serum and placental interleukin-18 are elevated in preeclampsia.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Huang Xiadi, Huang Hefeng, Dong Minyue, Yao Qiwei, Wang Hanzhi
Аннотация
OBJECTIVES: Interleukin-18 (IL-18) is a proinflammatory cytokine with pleiotrophic qualities and its roles in pregnancy, labor onset and pregnant complications have been proposed. However, the alterations of serum and placental IL-18 have been less investigated. The objective of the current investigation was to detect IL-18 concentrations in serum and placentas from patients with preeclampsia and women with normal pregnancy.
METHODS: 27 patients with preeclampsia and 28 women with normal pregnancy were recruited. Blood and placental samples were taken and IL-18 concentrations in serum and placental homogenate were analyzed by enzyme-linked immunosorbent assay (ELISA). The levels of IL-18 in serum and placenta were compared between preeclampsia and control.
RESULTS: Both serum and placental levels of IL-18 were significantly increased in preeclampsia as compared with control (P=0.014 and 0.003, respectively). Serum and placental levels of IL-18 were not significantly different in preeclamptic women who received dexomethasone and those who did not (P=0.223 and 0.330, respectively). Serum and placental IL-18 levels were not significantly different between preeclamptic women who delivered before 36 complete gestational weeks and those who delivered after 36 complete weeks (P=0.616 and 0.869, respectively). There were no significant differences in serum and placental IL-18 between women with mild preeclampsia and those with severe preeclampsia (P=0.056 and 0.357, respectively).
CONCLUSIONS: Increased serum and placental levels of IL-18 were observed in preeclampsia. Those associations may offer insight into the pathogenesis of the disease.
METHODS: 27 patients with preeclampsia and 28 women with normal pregnancy were recruited. Blood and placental samples were taken and IL-18 concentrations in serum and placental homogenate were analyzed by enzyme-linked immunosorbent assay (ELISA). The levels of IL-18 in serum and placenta were compared between preeclampsia and control.
RESULTS: Both serum and placental levels of IL-18 were significantly increased in preeclampsia as compared with control (P=0.014 and 0.003, respectively). Serum and placental levels of IL-18 were not significantly different in preeclamptic women who received dexomethasone and those who did not (P=0.223 and 0.330, respectively). Serum and placental IL-18 levels were not significantly different between preeclamptic women who delivered before 36 complete gestational weeks and those who delivered after 36 complete weeks (P=0.616 and 0.869, respectively). There were no significant differences in serum and placental IL-18 between women with mild preeclampsia and those with severe preeclampsia (P=0.056 and 0.357, respectively).
CONCLUSIONS: Increased serum and placental levels of IL-18 were observed in preeclampsia. Those associations may offer insight into the pathogenesis of the disease.