Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 1997
Multidrug intravenous sedation: determinants of the sedative dose of midazolam.
Клиническое исследованиеСтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Moore P A, Finder R L, Jackson D L
Аннотация
OBJECTIVES: The efficacy of multidrug intravenous sedation regimens in oral surgery is based on the ability to titrate opioids, benzodiazepines, and barbiturates to a desired level of relaxation. Dosage requirements to reach the initial sedation end points of slurred speech and ptosis of eyelids vary widely from one patient to another.
STUDY DESIGN: An assessment of physical, cardiovascular, behavioral, and pharmacologic factors that might predict midazolam dosage requirements for the initial sedation titration was carried out with data collected from a large controlled clinical trial of fentanyl, midazolam, and methohexital sedation for third molar surgery.
RESULTS: Dosage requirements for the initial titration of midazolam were found to be significantly higher when fentanyl was not included in the sedation regimen and when presedation heart rate and presedation systolic blood pressure were elevated.
STUDY DESIGN: An assessment of physical, cardiovascular, behavioral, and pharmacologic factors that might predict midazolam dosage requirements for the initial sedation titration was carried out with data collected from a large controlled clinical trial of fentanyl, midazolam, and methohexital sedation for third molar surgery.
RESULTS: Dosage requirements for the initial titration of midazolam were found to be significantly higher when fentanyl was not included in the sedation regimen and when presedation heart rate and presedation systolic blood pressure were elevated.
Предметные рубрики MeSH
AdolescentAdultAnalysis of VarianceAnesthesia, DentalAnesthetics, CombinedAnesthetics, IntravenousAnti-Anxiety AgentsBlood PressureChi-Square DistributionProcedural SedationDental AnxietyDose-Response Relationship, DrugDouble-Blind MethodFemaleFentanylHeart RateHumansHypnotics and SedativesMaleMethohexitalMidazolamMolar, ThirdPain MeasurementPreanesthetic MedicationTitrimetryTooth ExtractionTooth, Impacted