Renal physiology of the pig: application of stop-flow.

1. The stop-flow method in the pig, with modified kidneys, produced patterns for sodium, chloride, glucose and PAH that were similar to those obtained previously in other animals with simple kidneys. 2. Ethacrynic acid, under the conditions of the experiment, abolished distal sodium and chloride reabsorption in the pig. 3. We conclude that this method, viewed in perspective, could provide useful in situ information about the physiology of modified kidneys where the more difficult micropuncture and in vitro perfusion techniques are impractical.