An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium.
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Wong Ting Yat, Radua Joaquim, Pomarol-Clotet Edith, Salvador Raymond, Albajes-Eizagirre Anton, Solanes Aleix, Canales-Rodriguez Erick J, Guerrero-Pedraza Amalia, Sarro Salvador, Kircher Tilo, Nenadic Igor, Krug Axel, Grotegerd Dominik, Dannlowski Udo, Borgwardt Stefan, Riecher-Rössler Anita, Schmidt Andre, Andreou Christina, Huber Christian G, Turner Jessica, Calhoun Vince, Jiang Wenhao, Clark Sarah, Walton Esther, Spalletta Gianfranco, Banaj Nerisa, Piras Fabrizio, Ciullo Valentina, Vecchio Daniela, Lebedeva Irina, Tomyshev Alexander S, Kaleda Vasily, Klushnik Tatyana, Filho Geraldo Busatto, Zanetti Marcus Vinicius, Serpa Mauricio Henriques, Penteado Rosa Pedro Gomes, Hashimoto Ryota, Fukunaga Masaki, Richter Anja, Krämer Bernd, Gruber Oliver, Voineskos Aristotle N, Dickie Erin W, Tomecek David, Skoch Antonin, Spaniel Filip, Hoschl Cyril, Bertolino Alessandro, Bonvino Aurora, Di Giorgio Annabella, Holleran Laurena, Ciufolini Simone, Marques Tiago Reis, Dazzan Paola, Murray Robin, Lamsma Jelle, Cahn Wiepke, van Haren Neeltje, Díaz-Zuluaga Ana M, Pineda-Zapata Julián A, Vargas Cristian, López-Jaramillo Carlos, van Erp Theo G M, Gur Ruben C, Nickl-Jockschat Thomas
Аннотация
METHOD: To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.
RESULTS: The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.
CONCLUSION: These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.