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Войти в исследования Fertility and sterility · 2008
Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum.
СтатьяМногоцентровое исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Meeker John D, Rossano Mary G, Protas Bridget, Padmanahban Vasantha, Diamond Michael P, Puscheck Elizabeth, Daly Douglas, Paneth Nigel, Wirth Julia J
Аннотация
OBJECTIVE: To explore associations between exposure to metals and male reproductive hormone levels.
DESIGN: Cross-sectional epidemiology study with adjustment for potential confounders.
SETTING: University Medical Center.
PATIENT(S): Men recruited through two infertility clinics in Michigan.
INTERVENTION(S): Metal concentrations and reproductive hormone levels were measured in blood samples collected from 219 men.
MAIN OUTCOME MEASURE(S): Serum FSH, LH, inhibin B, T, and sex hormone-binding globulin levels.
RESULT(S): Cadmium, copper, and lead were all significantly or suggestively positively associated with T when modeled individually, findings that are consistent with limited previous human and animal studies. Conversely, molybdenum was associated with reduced T. A significant inverse trend between molybdenum and T remained when additionally considering other metals in the model, and a positive association between T and zinc was also found. Finally, in exploratory analysis there was evidence for an interaction between molybdenum and zinc, whereby high molybdenum was associated with a 37% reduction in T (relative to the population median level) among men with low zinc.
CONCLUSION(S): Although reductions in T and reproductive toxicity after molybdenum exposure have been previously demonstrated in animal studies, more research is needed to determine whether molybdenum poses a risk to human reproductive health.
DESIGN: Cross-sectional epidemiology study with adjustment for potential confounders.
SETTING: University Medical Center.
PATIENT(S): Men recruited through two infertility clinics in Michigan.
INTERVENTION(S): Metal concentrations and reproductive hormone levels were measured in blood samples collected from 219 men.
MAIN OUTCOME MEASURE(S): Serum FSH, LH, inhibin B, T, and sex hormone-binding globulin levels.
RESULT(S): Cadmium, copper, and lead were all significantly or suggestively positively associated with T when modeled individually, findings that are consistent with limited previous human and animal studies. Conversely, molybdenum was associated with reduced T. A significant inverse trend between molybdenum and T remained when additionally considering other metals in the model, and a positive association between T and zinc was also found. Finally, in exploratory analysis there was evidence for an interaction between molybdenum and zinc, whereby high molybdenum was associated with a 37% reduction in T (relative to the population median level) among men with low zinc.
CONCLUSION(S): Although reductions in T and reproductive toxicity after molybdenum exposure have been previously demonstrated in animal studies, more research is needed to determine whether molybdenum poses a risk to human reproductive health.