Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia · 2016
[Karyomegalic interstitial nephritis: an atypical case].
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Dugo Mauro, Laurino Licia, Di Martino Annalisa, Brunello Anna, Caberlotto Adriana, Gatti Pierluigi, Mangino Margherita, Mastrosimone Stefania, Pasi Alessandra, Palminteri Giuseppe, Puggia Riccarda, Rizzolo Monica, Toffolo Katia, Virgilio Bice, Zagatti Riccardo, Maresca Maria Cristina
Аннотация
Karyomegalic interstitial nephritis (KIN) is a rare disease entity that was first described by Burry in 1974. The prevalence of this disease is less than 1% and its pathogenesis is unclear. KIN is characterized by chronic tubulointerstitial nephritis associated with enlarged tubular epithelial cell nuclei, which leads to progressive decline of renal function. The disease has no known treatment. Here, we report on a 50-year-old female patient who presented with asymptomatic progressive decline of renal function. Renal biopsy demonstrated chronic tubulointerstitial nephritis with markedly enlarged and hyperchromic nuclei of tubule epithelial cells the hallmark of karyomegalic nephritis. Clinical and pathologic findings of this case are discussed in light of the available literature.