Dendritic Cell Therapy in Chronic Viral Infections: Current Applications, Challenges, and Future Perspectives.

Dendritic cells (DCs) are multifunctional cells that wield considerable influence in the shaping and modulation of the immune system. In immunotherapy, DC therapy has emerged as a dynamic and versatile approach with significant potential for combating viral infections. As elucidated through the exploration of HIV, and viral hepatitis, the trajectory of DC therapy is marked by tangible progress and transformative potential. Insights gained from ongoing studies can lead to the design of more effective vaccines that harness the power of dendritic cells, potentially providing long-lasting immunity against viral infections. However, optimizing DC therapy presents several challenges that require dedicated efforts. This review focuses on the potential of DC-based vaccines as a treatment for chronic viral infections like HIV, HBV, and HCV, where the virus remains in the body and causes long-lasting problems with the immune system.