Медицинская библиотека · Antibiotics (Basel, Switzerland) · 2021

Sars-Cov-2 Infection in Patients on Long-Term Treatment with Macrolides in Spain: A National Cross-Sectional Study.

Meseguer Barros Carmen Marina, Alzueta Isturiz Natalia, Sainz de Rozas Aparicio Rita, Vizcaíno Rafael Aguilella, López Esteban Laura, Anaya Ordóñez Sonia, Lekue Alkorta Itxasne, Martín Suances Salvadora, Jiménez Arce Jorge Ignacio, Fernández Vicente Maite, Borrego Izquierdo Yolanda, Prieto Sánchez Raquel, Casado Casuso Silvia, Madridejos Rosa, Verde Carmen Marquina, Tomás Sanz Rosa, Oro Fernández María, Gallardo Borge Sara, Lázaro López Eva, Pina Gadea María Belén, Pereira Pía Mercedes, Maestre-Sánchez María Victoria, Ribes-Murillo Esther, Gómez de Oña Constanza, María Jesús Lallana Álvarez, Celaya Lecea Concepción, Prado Prieto María Ana, Aranguez Ruiz Aranzazu, Olmo Quintana Vicente, Villén Romero Noemí, Payá Giner Carolina, Lloret Callejo Angeles, Fernández Ferreiro Alvaro, Basagoiti Carreño Blanca, Iglesias Iglesias Ana Aurelia, Martín Alonso Antonio, Díez Alcántara Ana, Marco Tejón Esther, Lestón Vázquez Marta, Ariza Copado Mª Ángeles, Aparicio Cueva Marta, Escudero Vilaplana Belén, Nicieza Marisa, Picazo Sanchiz Gracia, Silva Riádigos Genma María, Sánchez Lucía Jamart, García Álvarez Ángel, García Bonilla Antonio, Herrero Delicado Rafael, Arroyo Pineda Virginia, de la Hija Belén, Troncoso Mariño Amelia, Tofiño González Isabel, Mateu García Mónica Susana, García Vázquez Pablo, Pérez Martín Joaquín, Fernández-Urrusuno Rocío

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The aim of this study was to know the prevalence and severity of COVID-19 in patients treated with long-term macrolides and to describe the factors associated with worse outcomes. A cross-sectional study was conducted in Primary Care setting. Patients with macrolides dispensed continuously from 1 October 2019 to 31 March 2020, were considered. Main outcome: diagnosis of coronavirus disease-19 (COVID-19). Secondary outcomes: symptoms, severity, characteristics of patients, comorbidities, concomitant treatments. A total of 3057 patients met the inclusion criteria. Median age: 73 (64-81) years; 55% were men; 62% smokers/ex-smokers; 56% obese/overweight. Overall, 95% of patients had chronic respiratory diseases and four comorbidities as a median. Prevalence of COVID-19: 4.8%. This was in accordance with official data during the first wave of the pandemic. The most common symptoms were respiratory: shortness of breath, cough, and pneumonia. Additionally, 53% percent of patients had mild/moderate symptoms, 28% required hospital admission, and 19% died with COVID-19. The percentage of patients hospitalized and deaths were 2.6 and 5.8 times higher, respectively, in the COVID-19 group (p < 0.001). There was no evidence of a beneficial effect of long-term courses of macrolides in preventing SARS-CoV-2 infection or the progression to worse outcomes in old patients with underlying chronic respiratory diseases and a high burden of comorbidity.

Для цитирования: Meseguer Barros Carmen Marina, Alzueta Isturiz Natalia, Sainz de Rozas Aparicio Rita, Vizcaíno Rafael Aguilella, López Esteban Laura, Anaya Ordóñez Sonia, Lekue Alkorta Itxasne, Martín Suances Salvadora, Jiménez Arce Jorge Ignacio, Fernández Vicente Maite, Borrego Izquierdo Yolanda, Prieto Sánchez Raquel, Casado Casuso Silvia, Madridejos Rosa, Verde Carmen Marquina, Tomás Sanz Rosa, Oro Fernández María, Gallardo Borge Sara, Lázaro López Eva, Pina Gadea María Belén, Pereira Pía Mercedes, Maestre-Sánchez María Victoria, Ribes-Murillo Esther, Gómez de Oña Constanza, María Jesús Lallana Álvarez, Celaya Lecea Concepción, Prado Prieto María Ana, Aranguez Ruiz Aranzazu, Olmo Quintana Vicente, Villén Romero Noemí, Payá Giner Carolina, Lloret Callejo Angeles, Fernández Ferreiro Alvaro, Basagoiti Carreño Blanca, Iglesias Iglesias Ana Aurelia, Martín Alonso Antonio, Díez Alcántara Ana, Marco Tejón Esther, Lestón Vázquez Marta, Ariza Copado Mª Ángeles, Aparicio Cueva Marta, Escudero Vilaplana Belén, Nicieza Marisa, Picazo Sanchiz Gracia, Silva Riádigos Genma María, Sánchez Lucía Jamart, García Álvarez Ángel, García Bonilla Antonio, Herrero Delicado Rafael, Arroyo Pineda Virginia, de la Hija Belén, Troncoso Mariño Amelia, Tofiño González Isabel, Mateu García Mónica Susana, García Vázquez Pablo, Pérez Martín Joaquín, Fernández-Urrusuno Rocío. Sars-Cov-2 Infection in Patients on Long-Term Treatment with Macrolides in Spain: A National Cross-Sectional Study.. Antibiotics (Basel, Switzerland). 2021. DOI: 10.3390/antibiotics10091039.

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