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DOI 10.1093/ijnp/pyz053

Медицинская библиотека · The international journal of neuropsychopharmacology · 2019

Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study.

Fountoulakis Konstantinos N, Dragioti Elena, Theofilidis Antonis T, Wikilund Tobias, Atmatzidis Xenofon, Nimatoudis Ioannis, Thys Erik, Wampers Martien, Hranov Luchezar, Hristova Trayana, Aptalidis Daniil, Milev Roumen, Iftene Felicia, Spaniel Filip, Knytl Pavel, Furstova Petra, From Tiina, Karlsson Henry, Walta Maija, Salokangas Raimo K R, Azorin Jean-Michel, Bouniard Justine, Montant Julie, Juckel Georg, Haussleiter Ida S, Douzenis Athanasios, Michopoulos Ioannis, Ferentinos Panagiotis, Smyrnis Nikolaos, Mantonakis Leonidas, Nemes Zsófia, Gonda Xenia, Vajda Dora, Juhasz Anita, Shrivastava Amresh, Waddington John, Pompili Maurizio, Comparelli Anna, Corigliano Valentina, Rancans Elmars, Navickas Alvydas, Hilbig Jan, Bukelskis Laurynas, Injac Stevovic Lidija, Vodopic Sanja, Esan Oluyomi, Oladele Oluremi, Osunbote Christopher, Rybakowski Janusz Κ, Wojciak Pawel, Domowicz Klaudia, Figueira Maria Luisa, Linhares Ludgero, Crawford Joana, Panfil Anca-Livia, Smirnova Daria, Izmailova Olga, Lecic-Tosevski Dusica, Temmingh Henk, Howells Fleur, Bobes Julio, Garcia-Portilla Maria Paz, García-Alvarez Leticia, Erzin Gamze, Karadağ Hasan, De Sousa Avinash, Bendre Anuja, Hoschl Cyril, Bredicean Cristina, Papava Ion, Vukovic Olivera, Pejuskovic Bojana, Russell Vincent, Athanasiadis Loukas, Konsta Anastasia, Stein Dan, Berk Michael, Dean Olivia, Tandon Rajiv, Kasper Siegfried, De Hert Marc

СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

INTRODUCTION

A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.

METHODS

Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.

RESULTS

Exploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients.

DISCUSSION: This study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.

Для цитирования: Fountoulakis Konstantinos N, Dragioti Elena, Theofilidis Antonis T, Wikilund Tobias, Atmatzidis Xenofon, Nimatoudis Ioannis, Thys Erik, Wampers Martien, Hranov Luchezar, Hristova Trayana, Aptalidis Daniil, Milev Roumen, Iftene Felicia, Spaniel Filip, Knytl Pavel, Furstova Petra, From Tiina, Karlsson Henry, Walta Maija, Salokangas Raimo K R, Azorin Jean-Michel, Bouniard Justine, Montant Julie, Juckel Georg, Haussleiter Ida S, Douzenis Athanasios, Michopoulos Ioannis, Ferentinos Panagiotis, Smyrnis Nikolaos, Mantonakis Leonidas, Nemes Zsófia, Gonda Xenia, Vajda Dora, Juhasz Anita, Shrivastava Amresh, Waddington John, Pompili Maurizio, Comparelli Anna, Corigliano Valentina, Rancans Elmars, Navickas Alvydas, Hilbig Jan, Bukelskis Laurynas, Injac Stevovic Lidija, Vodopic Sanja, Esan Oluyomi, Oladele Oluremi, Osunbote Christopher, Rybakowski Janusz Κ, Wojciak Pawel, Domowicz Klaudia, Figueira Maria Luisa, Linhares Ludgero, Crawford Joana, Panfil Anca-Livia, Smirnova Daria, Izmailova Olga, Lecic-Tosevski Dusica, Temmingh Henk, Howells Fleur, Bobes Julio, Garcia-Portilla Maria Paz, García-Alvarez Leticia, Erzin Gamze, Karadağ Hasan, De Sousa Avinash, Bendre Anuja, Hoschl Cyril, Bredicean Cristina, Papava Ion, Vukovic Olivera, Pejuskovic Bojana, Russell Vincent, Athanasiadis Loukas, Konsta Anastasia, Stein Dan, Berk Michael, Dean Olivia, Tandon Rajiv, Kasper Siegfried, De Hert Marc. Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study.. The international journal of neuropsychopharmacology. 2019. DOI: 10.1093/ijnp/pyz053.

Предметные рубрики MeSH

AdultDisease ProgressionEuropeFactor Analysis, StatisticalFemaleHumansMaleMiddle AgedNigeriaPsychiatric Status Rating ScalesSchizophreniaSotos SyndromeYoung Adult
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