Cyanoacrylate glue for securing peripherally inserted intravenous catheters in the emergency department: A meta-analysis of randomized controlled trials.

BACKGROUND

Intravenous catheters (IVCs) are a common medical device, used in 70% of hospital patients. Due to their high failure ratio (35%-50%) and complications, we aimed to perform a systematic review and meta-analysis to assess the efficacy of Cyanoacrylate Glue (CG) use in preventing IV complications at the Emergency Department.

METHODS

This study was registered in PROSPERO on February 5, 2025, with registry number CRD42025642588 and received no financial support. A systematic search at PubMed, Embase, and Cochrane databases was performed and only Randomized Controlled Trials about CG use for securing IVCs were included.

RESULTS

Primary outcomes showed no statistical significance between the groups across all four outcomes at maximum follow-up. However, in a subgroup analysis including only adult patients, CG group presented lower IVCs dislodgement and failure events. Further studies in pediatric patients are needed.