The Journal of biological chemistry · 2014
Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Borahay Mostafa A, Kilic Gokhan S, Yallampalli Chandrasekha, Snyder Russell R, Hankins Gary D V, Al-Hendy Ayman, Boehning Darren
Аннотация
Statins are drugs commonly used for the treatment of high plasma cholesterol levels. Beyond these well known lipid-lowering properties, they possess broad-reaching effects in vivo, including antitumor effects. Statins inhibit the growth of multiple tumors. However, the mechanisms remain incompletely understood. Here we show that simvastatin inhibits the proliferation of human leiomyoma cells. This was associated with decreased mitogen-activated protein kinase signaling and multiple changes in cell cycle progression. Simvastatin potently stimulated leiomyoma cell apoptosis in a manner mechanistically dependent upon apoptotic calcium release from voltage-gated calcium channels. Therefore, simvastatin possesses antitumor effects that are dependent upon the apoptotic calcium release machinery.
Предметные рубрики MeSH
ApoptosisBlotting, WesternCalciumCalcium Channels, L-TypeCell CycleCell Line, TumorCell ProliferationCell SurvivalChelating AgentsCytosolDose-Response Relationship, DrugEgtazic AcidHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLeiomyomaMAP Kinase Signaling SystemMicroscopy, FluorescenceMitogen-Activated Protein KinasesPhosphorylationSimvastatin