International journal of radiation biology · 2026
Somatic copy number variations as long-term genomic biomarkers of ionizing radiation exposure in individuals accidentally exposed to Cesium-137 during the Goiânia radiological accident.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pereira Samara Socorro Silva, Pinto Irene Plaza, Ferreira da Silva Juliana, Oliveira Lorraynne Guimarães, Carneiro Silva Rafael, Cortazio do Prado Santos Victor, Lopes de Souza Nayara, da Silva Cláudio Carlos, Silva Daniela de Melo E, Cruz Aparecido Divino da
Аннотация
INTRODUCTION: Ionizing radiation (IR) is a well-established mutagen capable of inducing structural genomic alterations. The 1987 Goiânia radiological accident involving Caesium-137 represents one of the most significant cases of accidental human exposure to IR outside nuclear facilities.
OBJECTIVE: This study aimed to investigate the occurrence of somatic copy number variations (CNVs) as potential biomarkers of IR exposure in individuals accidentally exposed to Cesium-137.
METHODS: A case-control study was conducted including 20 exposed and 25 non-exposed individuals. Chromosomal microarray analysis (CMA) using the GeneChip® CytoScan HD platform was applied to detect autosomal CNVs. Statistical analyses included ANOVA, linear regression, and odds ratio estimation to assess dose-response relationships and associations with age.
RESULTS: Exposed individuals exhibited a 33.6% overall increase in CNV burden compared with controls, with CNV losses rising by 70% and gains by 46%. Linear regression revealed a positive dose-response relationship, with each 1 Gy of absorbed dose increasing CNV losses and gains by 0.65 and 0.58 lnCNV units, respectively. Age and radiation dose jointly influenced CNV frequency. Chromosome 10 showed the highest CNV density, and deletions predominated over duplications.
CONCLUSION: The findings demonstrated that somatic CNVs persist as quantifiable genomic signatures of ionizing radiation exposure even decades after the event. CNV profiling represents a promising tool for retrospective biodosimetry and long-term health surveillance of exposed populations, reinforcing its potential role in radiological protection and genomic risk assessment frameworks.
OBJECTIVE: This study aimed to investigate the occurrence of somatic copy number variations (CNVs) as potential biomarkers of IR exposure in individuals accidentally exposed to Cesium-137.
METHODS: A case-control study was conducted including 20 exposed and 25 non-exposed individuals. Chromosomal microarray analysis (CMA) using the GeneChip® CytoScan HD platform was applied to detect autosomal CNVs. Statistical analyses included ANOVA, linear regression, and odds ratio estimation to assess dose-response relationships and associations with age.
RESULTS: Exposed individuals exhibited a 33.6% overall increase in CNV burden compared with controls, with CNV losses rising by 70% and gains by 46%. Linear regression revealed a positive dose-response relationship, with each 1 Gy of absorbed dose increasing CNV losses and gains by 0.65 and 0.58 lnCNV units, respectively. Age and radiation dose jointly influenced CNV frequency. Chromosome 10 showed the highest CNV density, and deletions predominated over duplications.
CONCLUSION: The findings demonstrated that somatic CNVs persist as quantifiable genomic signatures of ionizing radiation exposure even decades after the event. CNV profiling represents a promising tool for retrospective biodosimetry and long-term health surveillance of exposed populations, reinforcing its potential role in radiological protection and genomic risk assessment frameworks.