[CD69 expression on T cell surface in patients with obstructive sleep apnea hypopnea syndrome].

Objective

To investigate the detection and significance of T cell CD69 expression in peripheral blood of patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Method:According to AHI, 81 OSAHS patients diagnosed by PSG were divided into 3 groups: light, medium and heavy, with 27 cases in each group; 27 patients without OSAHS as control group. Flow cytometry was used to detect the expression rate of CD69 in T cells, to analyze the correlation between the expression rate of CD69 on T cells and the gender, age, BMI, and PSG index.Result:①The CD69 expression rate of T cells in peripheral blood of OSAHS patients with snoring degree increases gradually (P< 0.05); Comparison between the two shows that there was no significant difference in CD69 expression rate on T cells between the control group and the mild group (t= 1.649, P> 0.05); there were significant differences between the other groups (P< 0.05). ②The CD69 expression rate of T cells in peripheral blood of OSAHS patients has no correlation with BMI, age and gender (P> 0.05), were positively correlated with AHI, negatively correlated with LSaO₂ (P< 0.01). ③The CD69 expression rate of T cells and AHI in 27 cases of severe OSAHS patients with a comprehensive treatment has significantly reduced, LSaO₂ increased significantly (P< 0.01).

Conclusion

Increased expression of CD69 in peripheral blood T cells may be one of the mechanisms of OSAHS complicated with cardiovascular disease. Detection of CD69 expression rate in T cells for reflecting the degree of disease in patients with OSAHS, assessment of risk of cardiovascular damage, have certain clinical significance.