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Войти в исследования Scientific reports · 2022
Correlation between COVID-19 severity and previous exposure of patients to Borrelia spp.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Szewczyk-Dąbrowska Alina, Budziar Wiktoria, Harhala Marek, Baniecki Krzysztof, Pikies Aleksandra, Jędruchniewicz Natalia, Kaźmierczak Zuzanna, Gembara Katarzyna, Klimek Tomasz, Witkiewicz Wojciech, Nahorecki Artur, Barczyk Kamil, Kłak Marlena, Grata-Borkowska Urszula, Dąbrowska Krystyna
Аннотация
Predictors for the risk of severe COVID-19 are crucial for patient care and control of the disease. Other infectious diseases as potential comorbidities in SARS-CoV-2 infection are still poorly understood. Here we identify association between the course of COVID-19 and Lyme disease (borreliosis), caused by Borrelia burgdorferi transmitted to humans by ticks. Exposure to Borrelia was identified by multi-antigenic (19 antigens) serological testing of patients: severe COVID-19 (hospitalized), asymptomatic to mild COVID-19 (home treated or not aware of being infected), and not infected with SARS-CoV-2. Increased levels of Borrelia-specific IgGs strongly correlated with COVID-19 severity and risk of hospitalization. This suggests that a history of tick bites and related infections may contribute to the risks in COVID-19. Though mechanisms of this link is not clear yet, screening for antibodies targeting Borrelia may help accurately assess the odds of hospitalization for SARS-CoV-2 infected patients, supporting efforts for efficient control of COVID-19.