[Toxicity studies of VP 16-213 (VI)--Antigenicity in guinea pigs].

VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, and VP-protein conjugates were examined for their antigenic properties using male Hartley guinea pigs. The results of systemic anaphylaxis test, passive cutaneous anaphylaxis test, passive hemagglutination test and Schultz-Dale reaction revealed that VP possessed neither antigenic nor haptenic properties. The dose levels of VP employed in the present experiment were confirmed not to suppress immune reactions.