Gas chromatographic determination of nitrogen-containing anticonvulsant drugs and opium alkaloids using a thermoaerosol detector.

A simple and sensitive gas chromatographic method for determining nitrogen-containing anticonvulsant drugs (phenobarbital, hexamidine and diphenylhydantoin) and opium alkaloids (codeine, morphine, papaverin and narcotin) with a thermoaerosol detector is described. All the compounds were determined by using 0.1-0.2 ml of plasma and without their transformation into volatile derivatives. Packed glass columns and quartz capillary columns of short lengths were employed.