Journal of cosmetic dermatology · 2025
Enhancing Facial Projection: Efficacy and Safety of a Novel Filler Combining Cross-Linked Sodium Hyaluronate Gel With Poly-L-Lactic Acid-b-PEG Microspheres for T-Zone Augmentation.
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Wang Shiwei, Qiu Yinxian, Zhu Mengjie, Zou Muyan, Chen Wei, Qiao Guanqun, Li Jialun, Wu Jiaxu, Diao Yujia, Cai Wei
Аннотация
BACKGROUND: The nose, eyebrow, and forehead are critical elements of the T-zone, vital for enhancing facial three-dimensionality. Many Asians seek a more contoured and sculpted facial appearance by T-zone augmentation. The novel poly-L-lactic acid microsphere and hyaluronic acid suspension (PLLA-b-PEG/HA) has proven to be a safe and effective dermal filler, making it an appealing choice for individuals aiming for T-zone augmentation.
OBJECTIVE: To retrospectively assess the efficacy and safety of PLLA-b-PEG/HA injection into the T-zone for aesthetic enhancement.
METHODS: Fifteen participants were included in this study. A comprehensive clinical evaluation was performed, including measurements of total facial convexity angle and radix height, the FACE-Q scales for satisfaction with the nose, forehead, and eyebrows, the Global Aesthetic Improvement Scale (GAIS), and a 7-item satisfaction scale. Tissue in the peri-eyebrow area was examined 12 months posttreatment for comparison with normal tissues.
RESULTS: Significant increases in radix height and total facial convexity angle were observed at each follow-up visit (p < 0.05). FACE-Q scores also showed significant improvements from baseline in the eyebrows, forehead, and nose at each posttreatment visit (p < 0.001). The GAIS improvement rate remained high, with 80.00% reported by participants and 86.67% by blinded evaluators 12 months after treatment. The satisfaction rate was 73.3% at this time interval. Pathological examinations demonstrated newly formed collagen fibers and microvessels, with no abnormal pathological structure.
CONCLUSION: The PLLA-b-PEG/HA demonstrates efficacy in enhancing the T-zone (nose, eyebrow, and forehead) with a favorable safety profile.
OBJECTIVE: To retrospectively assess the efficacy and safety of PLLA-b-PEG/HA injection into the T-zone for aesthetic enhancement.
METHODS: Fifteen participants were included in this study. A comprehensive clinical evaluation was performed, including measurements of total facial convexity angle and radix height, the FACE-Q scales for satisfaction with the nose, forehead, and eyebrows, the Global Aesthetic Improvement Scale (GAIS), and a 7-item satisfaction scale. Tissue in the peri-eyebrow area was examined 12 months posttreatment for comparison with normal tissues.
RESULTS: Significant increases in radix height and total facial convexity angle were observed at each follow-up visit (p < 0.05). FACE-Q scores also showed significant improvements from baseline in the eyebrows, forehead, and nose at each posttreatment visit (p < 0.001). The GAIS improvement rate remained high, with 80.00% reported by participants and 86.67% by blinded evaluators 12 months after treatment. The satisfaction rate was 73.3% at this time interval. Pathological examinations demonstrated newly formed collagen fibers and microvessels, with no abnormal pathological structure.
CONCLUSION: The PLLA-b-PEG/HA demonstrates efficacy in enhancing the T-zone (nose, eyebrow, and forehead) with a favorable safety profile.